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How Does Deflux Work? - Palette Life Sciences

Deflux® is a sterile, highly viscous gel of dextranomer microspheres (50 mg/mL) in a carrier gel of non-animal stabilized hyaluronic acid (15 mg/mL), constituting a biocompatible and biodegradable implant.

The dextranomer microspheres range in size between 80-250 microns with an average size of about 130 microns.

The stabilized hyaluronic acid acts mainly as a carrier, leaving the dextranomer microspheres at the implant site.

Deflux consists of two types of biosynthesized polysaccharides: dextranomer microspheres and hyaluronic acid of nonanimal origin. (1)

Deflux is injected submucosally in the urinary bladder in close proximity to the ureteral orifice. The injection of Deflux creates increased tissue bulk thereby providing coaptation of the distal ureter during filling and contraction of the bladder. Over time, the gel combines with the fibroblasts and collagen, which stabilize the position and size of the implant. (1)

The Deflux implant does not disappear over time and does not migrate from the injection site (2,3)

Deflux should only be administered by qualified surgeons experienced in the use of a cystoscope and trained in subureteral injection procedures.


1. Deflux [prescribing information]. Santa Barbara, CA: Palette Life Sciences, Inc.; 2019.

2. Cerwinka WH, Scherz HC, Kirsch AJ. Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. Adv Urol. 2008; 1-7.

3. Stenberg A, Larsson E, Läckgren G. Endoscopic treatment with dextranomer-hyaluronic acid for vesicoureteral reflux: histological findings. J Urol. 2003;169:1109-1113.